One of the most prevalent misconceptions about Bone Marrow Derived Progenitor Treatments is that these are “stem cell” treatments alone. In fact, a small fraction of cells that contain DNA within a bone marrow aspirate are “stem cells.” In actuality two generally accepted “stem cell” lines are present in bone marrow aspirate,
Mesenchymal Stem Cells (MSCs) and Hematopoetic Stem Cells (HSCs). MSCs have captured the spotlight, however, the actual mechanism of action of MSCs on tissue repair is co-dependent on many of the other cells present in the bone marrow. One such example of this is the regulation of bone remodeling by MSCs.
The abstract below is from a research paper that illustrates MSC activation along a bone remodeling pathway by stimulation of Extracellular Vesicles (EVs) released by Monocytes (another nucleated cell type present in bone marrow). When contacted by these EVs, MSCs express Matrix Metalloproteinases necessary for bone remodeling. What does that mean? It means we know very little. It means the true potential of our body’s master repair cell, MSCs, is dependent on interaction with other cell types, each directing the director. Stem Cell Science, just as quickly rewritten as written.